STAT1 antibody
In stock
SKU/Catalog Number
PAab09985
Catalog Number: PAab09985
- Isotype IgG.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- Signal transducer and transcription activator that mediates cellular responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of IFN-stimulated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
- Immunogen signal transducer and activator of transcription 1, 91kDa.
- Specificity Human, Rat.
- Tested Application ELISA, WB, IHC.
- Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:500.
- IHC use Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab09985(STAT1 Antibody) at dilution of 1:200.
- WB use.
- Rat liver tissue were subjected to SDS PAGE followed by western blot with PAab09985(STAT1 antibody) at dilution of 1:1000.
- Protein Information.
- Gene ID 6772.
- Uniprot ID P42224.
- Calculated MW 84 kDa.
- Research Area Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology.
- Alternative Name ISGF 3, STAT1, STAT91.
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab09985 |
| Manufacturer | Life Science Market |
| Certification | For research only |
| Order | Request Quote |
