RANKL antibody
In stock
SKU/Catalog Number
PAab09838
Catalog Number: PAab09838
- Isotype IgG1.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
- Immunogen tumor necrosis factor (ligand) superfamily, member 11.
- Specificity Human.
- Tested Application ELISA, WB.
- Recommended dilution WB: 1:1000-1:5000.
- IHC use.
- WB use.
- Hela cells were subjected to SDS PAGE followed by western blot with PAab09838(RANKL antibody) at dilution of 1:3000.
- Protein Information.
- Gene ID 8600.
- Uniprot ID O14788.
- Calculated MW 17 kDa.
- Research Area Immunology, Signal Transduction, Developmental biology.
- Alternative Name CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE.
| Intended Use | Purification Protein A+G purification , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab09838 |
| Manufacturer | Life Science Market |
| Certification | For research only |
| Order | Request Quote |
