Phospho-CHEK1-S280 antibody
In stock
SKU/Catalog Number
PAab09816
Catalog Number: PAab09816
- Isotype IgG.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
- Immunogen Phospho-CHEK1-S280.
- Specificity Human, Mouse.
- Tested Application ELISA, WB, IHC, IF.
- Recommended dilution WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200.
- IHC use Immunofluorescence analysis of MCF-7 cells using PAab09816. Blue: DAPI for nuclear staining.
- WB use HT-29 cells were subjected to SDS PAGE followed by western blot with PAab09816 at dilution of 1:1000.
- Protein Information.
- Gene ID 1111.
- Uniprot ID O14757.
- Calculated MW 60 kDa.
- Research Area.
- Alternative Name CHK1.
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab09816 |
| Manufacturer | Life Science Market |
| Certification | For research only |
| Order | Request Quote |
