MAP3K3 antibody
In stock
SKU/Catalog Number
PAab09784
Catalog Number: PAab09784
- Isotype IgG
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
- Background/ FUNCTION
- The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.
- Immunogen mitogen-activated protein kinase kinase kinase 3
- Specificity Human
- Tested Application ELISA, WB, IHC
- Recommended dilution WB: 1:200-1:2000; IHC: 1:50-1:500
- IHC use Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using PAab09784(MAP3K3 Antibody) at dilution of 1:100
- WB use
- HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09784(MAP3K3 Antibody) at dilution of 1:300
- Protein Information
- Gene ID 4215
- Uniprot ID Q99759
- Calculated MW 74 kDa
- Research Area Signal Transduction, Immunology
- Alternative Name MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK 3, MEKK3
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab09784 |
| Manufacturer | Life Science Market |
| Certification | For research only |
| Order | Request Quote |
