DDR1 antibody
In stock
SKU/Catalog Number
PAab10051
Catalog Number: PAab10051
- Isotype IgG
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
- Background/ FUNCTION
- Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing(By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
- Immunogen discoidin domain receptor tyrosine kinase 1
- Specificity Human
- Tested Application ELISA, WB
- Recommended dilution WB: 1:500 - 1:2000
- IHC use
- WB use
- U87MG cells were subjected to SDS PAGE followed by western blot with PAab10051(DDR1 antibody) at dilution of 1:1000.
- Protein Information
- Gene ID 780
- Uniprot ID Q08345
- Calculated MW 101 kDa
- Research Area Immunology, Cardiovascular, Metabolism, Signal Transduction
- Alternative Name CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
| Intended Use | Purification Immunogen affinity purified, Purity 95% as determined by SDS-PAGE |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab10051 |
| Manufacturer | Life Science Market |
| Certification | For research only |
| Order | Request Quote |
