Caspase 8 antibody
In stock
SKU/Catalog Number
PAab10024
Catalog Number: PAab10024
- Isotype IgG
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
- Background/ FUNCTION
- Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.
- Immunogen caspase 8, apoptosis-related cysteine peptidase
- Specificity Human, Mouse
- Tested Application ELISA, WB, IHC
- Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:500
- IHC use Immunohistochemistry of paraffin-embedded mouse kidney using PAab10024(CASP8 antibody) at dilution of 1:100
- WB use
- Jurkat cells were subjected to SDS PAGE followed by western blot with PAab10024(CASP8 antibody) at dilution of 1:1000
- Protein Information
- Gene ID 841
- Uniprot ID Q14790
- Calculated MW 50-55 kDa, 25-32 kDa
- Research Area Signal Transduction, Metabolism, cancer
- Alternative Name Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5
| Intended Use | Purification Immunogen affinity purified, Purity 95% as determined by SDS-PAGE |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab10024 |
| Manufacturer | Life Science Market |
| Certification | For research only |
| Order | Request Quote |
