Caspase 3 antibody
In stock
SKU/Catalog Number
PAab10013
Catalog Number: PAab10013
- Isotype IgG
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
- Background/ FUNCTION
- Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. The antibody can recognize p17 and p32 of Caspase 3.
- Immunogen caspase 3, apoptosis-related cysteine peptidase
- Specificity Human, Mouse, Rat
- Tested Application ELISA, WB, IHC
- Recommended dilution WB: 1:200-1:2000; IHC: 1:50-1:500
- IHC use Immunohistochemistry of paraffin-embedded mouse heart tissue slide using PAab10013(CASP3 Antibody) at dilution of 1:100 WB use Jurkat cells were subjected to SDS PAGE followed by western blot with PAab10013(CASP3 antibody) at dilution of 1:1000
- Protein Information
- Gene ID
- Uniprot ID P42574
- Calculated MW 32-35 kDa, 17 kDa
- Research Area Cancer, Metabolism, Neuroscience
- Alternative Name Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1
| Intended Use | Purification Immunogen affinity purified, Purity 95% as determined by SDS-PAGE |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab10013 |
| Manufacturer | Life Science Market |
| Certification | For research only |
| Order | Request Quote |
