AGER antibody

Isotype IgG1 ,Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.) ,Background/ FUNCTION ,Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. ,Immunogen advanced glycosylation end product-specific receptor ,Specificity Human, Rat ,Tested Application ELISA, WB ,Recommended dilution WB: 1:1000-1:5000 ,IHC use ,WB use ,Rar lung tissue were subjected to SDS PAGE followed by western blot with PAab09951(AGER Antibody) at dilution of 1:2000 ,Protein Information ,Gene ID 177 ,Uniprot ID Q15109 ,Calculated MW 43 kDa ,Research Area Immunology, Signal Transduction, Developmental biology