VEGF antibody
Auf Lager
SKU/Catalog Number
PAab09933
Katalognummer: PAab09933
- Isotype IgG2b.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1(MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010). This antibody can recognize all the isoforms of VEFGA.
- Immunogen vascular endothelial growth factor A.
- Specificity Human.
- Tested Application ELISA, WB, IHC.
- Recommended dilution WB: 1:1000-1:4000; IHC: 1:50-1:500.
- IHC use Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using PAab09933 (VEGF antibody) at dilution of 1:200.
- WB use.
- MCF-7 cells were subjected to SDS PAGE followed by western blot with PAab09933 (VEGF antibody) at dilution of 1:2000.
- Protein Information.
- Gene ID.
- Uniprot ID P15692.
- Calculated MW 45 kDa.
- Research Area Signal Transduction, Cardiovascular, Cancer, Immunology, Developmental biology.
- Alternative Name L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGFA, VPF.
| Intended Use | Purification protein A+G purified , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab09933 |
| Hersteller | Life Science Market |
| Zertifizierung | For research only |
| Order | Request Quote |
