USP10 antibody
Auf Lager
SKU/Catalog Number
PAab10128
Katalognummer: PAab10128
- Isotype IgG.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989).
- Immunogen ubiquitin specific peptidase 10.
- Specificity Human, Mouse.
- Tested Application ELISA, IHC, IF.
- Recommended dilution IHC: 1:50-1:200; IF: 1:20-1:100.
- IHC use Immunohistochemistry of paraffin-embedded mouse brain tissue slide using PAab10128 (USP10 Antibody) at dilution of 1:100.
- WB use.
- Protein Information.
- Gene ID 9100.
- Uniprot ID Q14694.
- Calculated MW Research Area Epigenetics, Metabolism.
- Alternative Name Deubiquitinating enzyme 10, KIAA0190, Ubiquitin thiolesterase 10, UBPO, USP10.
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab10128 |
| Hersteller | Life Science Market |
| Zertifizierung | For research only |
| Order | Request Quote |
