TRAF2 antibody
Auf Lager
SKU/Catalog Number
PAab10115
Katalognummer: PAab10115
- Isotype IgG.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
- Immunogen TNF receptor-associated factor 2.
- Specificity Human, Mouse, Rat.
- Tested Application ELISA, WB, IF, IHC.
- Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500.
- IHC use.
- Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using PAab10115( TRAF2 Antibody) at dilution of 1:200.
- WB use.
- HeLa cells were subjected to SDS PAGE followed by western blot with PAab10115 (TRAF2 antibody) at dilution of 1:1000.
- Protein Information.
- Gene ID 7186.
- Uniprot ID Q12933.
- Calculated MW 54 kDa.
- Research Area Epigenetics, Signal Transduction, Metabolism.
- Alternative Name TRAF2, TRAP, TRAP3.
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab10115 |
| Hersteller | Life Science Market |
| Zertifizierung | For research only |
| Order | Request Quote |
