PTEN antibody
Auf Lager
SKU/Catalog Number
PAab09821
Katalognummer: PAab09821
- Isotype IgG.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
- Immunogen phosphatase and tensin homolog.
- Specificity Human, Mouse, Rat, Monkey.
- Tested Application ELISA, WB, IHC.
- Recommended dilution WB: 1:500 - 1:2000; IHC: 1:50 - 1:100.
- IHC use Immunohistochemistry of paraffin-embedded mouse brain slide using PAab09821( PTEN Antibody) at dilution of 1:100.
- WB use.
- Hela cells were subjected to SDS PAGE followed by western blot with PAab09821( PTEN Antibody) at dilution of 1:1000.
- Protein Information.
- Gene ID 5728.
- Uniprot ID P60484.
- Calculated MW 53 kDa.
- Research Area Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Neuroscience, Stem Cells, Cell Division and Proliferation.
- Alternative Name MMAC1, TEP1.
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab09821 |
| Hersteller | Life Science Market |
| Zertifizierung | For research only |
| Order | Request Quote |
