Phospho- MAPK14(T180/Y182) antibody
Auf Lager
SKU/Catalog Number
PAab10117
Katalognummer: PAab10117
- Isotype IgG.
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.).
- Background/ FUNCTION.
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
- Immunogen A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK.
- Specificity Human.
- Tested Application ELISA, WB.
- Recommended dilution WB: 1:500-1:2000.
- IHC use.
- WB use.
- Hela cells were subjected to SDS PAGE followed by western blot with PAab10117 at dilution of 1:1000.
- Protein Information.
- Gene ID 1432.
- Uniprot ID Q16539.
- Calculated MW 41kDa.
- Research Area Cancer, Immunology, Signal Transduction, epigenetics.
- Alternative Name CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA.
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE. |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab10117 |
| Hersteller | Life Science Market |
| Zertifizierung | For research only |
| Order | Request Quote |
