The M65 EpiRat™ ELISA detects total amount of K18, which quantifies the total amount of cell death in epithelial cells. This allows for the use of the assay in different research fields such as in hepatology and oncology. In pre clinical studies, the M65 EpiRat™ ELISA can be used to analyse the effect of drugs on treatment effect and disease progression for example for new compounds in Non Alcoholic Fatty Liver (NAFL) and Non Alcoholic Steatohepatitis (NASH).
The M65 EpiRat™ ELISA is based on the M5 and M6 antibodies, which bind to the biomarker Keratin-18 (K18). K18 is an intermediate filament protein in epithelial cells.
