HMGCR antibody
Auf Lager
SKU/Catalog Number
PAab10055
Katalognummer: PAab10055
- Isotype IgG
- Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
- Background/ FUNCTION
- HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Immunogen 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- Specificity Human
- Tested Application ELISA, IHC
- Recommended dilution IHC: 1:20-1:200
- IHC use Immunohistochemistry of paraffin-embedded human colon cancer using PAab10055(HMGCR antibody) at dilution of 1:100
- WB use
- Protein Information
- Gene ID 3156
- Uniprot ID P04035
- Calculated MW 120 kDa
- Research Area Metabolism
- Alternative Name HMG CoA reductase, HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMDH
| Intended Use | Purification Immunogen affinity purified , Purity 95% as determined by SDS-PAGE |
|---|---|
| Company | bioactiva diagnostica GmbH |
| Storage condition | 2-8°C |
| Product Number | PAab10055 |
| Hersteller | Life Science Market |
| Zertifizierung | For research only |
| Order | Request Quote |
