E-cadherin antibody

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SKU/Catalog Number

Katalognummer: PAab10112

  • Isotype IgG2b
  • Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
  • Background/ FUNCTION
  • This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
  • Immunogen cadherin 1, type 1, E-cadherin (epithelial)
  • Specificity Human
  • Tested Application ELISA, IHC, WB, IF
  • Recommended dilution WB: 1:1000-1:5000; IHC: 1:500-1:2000; IF: 1:50-1:500
  • IHC use Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab10112( E-cadherin Antibody) at dilution of 1:1000
  • WB use
  • A431 cells were subjected to SDS PAGE followed by western blot with PAab10112(E-cadherin antibody) at dilution of 1:3000
  • Protein Information
  • Gene ID 999
  • Uniprot ID P12830
  • Calculated MW 130 kDa
  • Research Area Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells
  • Alternative Name Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin
Weitere Informationen
Intended UsePurification protein A+G purified, Purity 95% as determined by SDS-PAGE
Companybioactiva diagnostica GmbH
Storage condition2-8°C
Product NumberPAab10112
HerstellerLife Science Market
ZertifizierungFor research only
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