CASP3 antibody

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SKU/Catalog Number

Katalognummer: PAab09938

  • Isotype IgG1 
  • Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
  • Background/ FUNCTION
  • Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
  • Immunogen caspase 3, apoptosis-related cysteine peptidase
  • Specificity Human, Mouse, Rat
  • Tested Application ELISA, IHC, WB,IF
  • Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:300; IF: 1:50-1:200
  • IHC use Immunohistochemistry of paraffin-embedded human breast cancer using PAab09938(CASP3 antibody) at dilution of 1:200
  • WB use
  • Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with PAab09938 (CASP3 antibody) at dilution of 1:3000
  • Protein Information
  • Gene ID 836
  • Uniprot ID P42574 C
  • alculated MW 32-35 kDa, 19 kDa, 17 kDa
  • Research Area Cancer, Metabolism, Neuroscience
  • Alternative Name Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1
Weitere Informationen
Intended UsePurification protein A+G purified, Purity 95% as determined by SDS-PAGE
Companybioactiva diagnostica GmbH
Storage condition2-8°C
Product NumberPAab09938
HerstellerLife Science Market
ZertifizierungFor research only
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