Caspase 1 antibody

In stock
SKU/Catalog Number

Catalog Number: PAab10015

  • Isotype IgG 
  • Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
  • Background/ FUNCTION
  • CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.
  • Immunogen caspase 1
  • Specificity Human, Mouse
  • Tested Application ELISA, WB, IHC
  • Recommended dilution WB: 1:200-1:2000; IHC: 1:50-1:500
  • IHC use Immunohistochemistry of paraffin-embedded human stomach tissue slide using PAab10015(CASP1 Antibody) at dilution of 1:100
  • WB use
  • NIH/3T3 cells were subjected to SDS PAGE followed by western blot with PAab10015(CASP1 antibody) at dilution of 1:1000
  • Protein Information
  • Gene ID 834
  • Uniprot ID P29466
  • Calculated MW 45-47 kDa, 30 kDa, 35 kDa
  • Research Area Signal Transduction, Metabolism, Cardiovascular, Neuroscience
More Information
Intended UsePurification Immunogen affinity purified, Purity 95% as determined by SDS-PAGE
Companybioactiva diagnostica GmbH
Storage condition2-8°C
Product Number PAab10015
ManufacturerLife Science Market
CertificationFor research only
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